Current Publications (2005-06)

  • Zhou XF, Zhang L, Tseng E, Scott-Ramsay EA, Schentag JJ, Coburn RA, Morris ME. New 4-aryl-1,4-dihydropyridines and 4-arylpyridines as P-glycoprotein inhibitors, Drug Metab Disp 33(3):321-8, 2005.
  • Zhang S, Wang X, Sagawa K, Morris ME. Flavonoids chrysin and benzoflavone, potent BCRP inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b(-/-) mice, Drug Metab Disp 33(3):341-348, 2005.
  • Morris ME, Hu K, Wang Q. Renal Clearance of {gamma}-Hydroxybutyric Acid in Rats: Increasing Renal Elimination as a Detoxification Strategy. J Pharmacol Exp Ther 313(3):1194-202, 2005.
  • Zhou XF, Yang X, Wang Q, Coburn RA and Morris ME. Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: in vitro and in vivo studies. Drug Metab Disp 33:1220-1228, 2005.
  • Wang L and Morris ME. Liquid Chromatography-Tandem Mass Spectroscopy Assay for Quercetin and Conjugated Quercetin Metabolites in Human Plasma and Urine. J Chromatogr B Analyt Technol Biomed Life Sci. 821(2):194-201, 2005.
  • Zhang S, Yang X, Coburn RA and Morris ME. Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein. Biochem Pharmacol 70:627-639, 2005.
  • Zhou XF, Wang Q, Coburn RA and Morris ME. A high-performance liquid chromatographic method for determination of the niguldipine analogue DHP-014. Biomed Chromatogr 20:48-53, 2006.
  • Morris ME and Telang U. Isothiocyanates and Cancer Prevention. In Nutrition and Cancer Prevention, Awad AB and Bradford PG (editors), Marcel Dekker Inc, 2005.
  • Zhou XF, Coburn RA and Morris ME. Effects of new 4-aryl-1,4-dihydropyridines and 4-arylpyridines on drug efflux mediated by multidrug resistance-associated protein-1. J Pharm Sci. 94(10):2256-65, 2005.
  • Zhou XF, MacDiarmid, Coburn RA and Morris ME. Pharmacokinetics and bioavailability of a newly synthesized dihydropyridine compound with multidrug reversal activity. Biopharm Drug Dispos 26:279-285, 2005.
  • Zhou XF, Yang X, Wang Q, Coburn RA and Morris ME. Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: in vitro and in vivo studies. Drug Metab Disp 33(8):1220-8, 2005.
  • Hu K and Morris ME. Pharmacokinetics of naphthyl isothiocyanate in rats. J Pharm Sci 94(11):2441-51, 2005.
  • Ji Y, Kuo Y and Morris ME. Pharmacokinetics of dietary phenethyl isothiocyanate in rats, Pharm Res 22(10):1658-66, 2005.
  • Ji Y and Morris ME. Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein, Biochem Pharmacol 70:640-647, 2005.
  • Ji Y and Morris ME. Membrane Transport of Dietary Phenethyl Isothiocyanate by Breast Cancer Resistance Protein (ABCG2), Molecular Pharmaceutics 2(5):414-9, 2005.
  • Zhou XF, Shao Q, Coburn RA and Morris ME. Quantitative Structure-Activity Relationship and Quantitative Structure-Pharmacokinetics Relationship of 1,4-Dihydropyridines and Pyridines as Multidrug Resistance Modulators, Pharm Res 22:1989-1996, 2005.
  • Wang X, Wolkoff AW, and Morris ME. Flavonoids as a novel class of human organic anion transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metab Disp 33:1666-1672, 2005.
  • Zhang S and Morris ME: Efflux transporters in drug excretion. In Drug Delivery: Principles and Applications. Wang B (editor), John Wiley & Sons Inc., 2005, pp. 381-409.
  • Moon Y, Wang X and Morris ME: Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism, Toxicology In Vitro 20(2):187-210, 2006.
  • Morris ME and Zhang S. Flavonoid-Drug Interactions: Effects of flavonoids on ABC transporters. Life Sci 78(18):2116-2130, 2006.
  • Moon YJ, Sagawa K, Frederick K, Zhang S, and Morris ME. Pharmacokinetics and Bioavailability of the Isoflavone Biochanin A in Rats, AAPS Journal 8(3), article 51, 2006 (http://www.aapsj.org).
  • Wang Q, Darling IM and Morris ME. Transport of Gamma-hydroxybutyrate in Rat Kidney Membrane Vesicles - Role of Monocarboxylate Transporters. J Pharmacol Exp Ther. 318: 751-761, 2006.